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KMID : 0363320070280040850
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Journal of Korean Oriental Internal Medicine
2007 Volume.28 No. 4 p.850 ~ p.862
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The Case-Control Study of Risk Factors of Silent Cerebral Infarction
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Baek Hye-Ki
Ko Mi-Mi
Yu Byeong-Chan
Bang Ok-Sun
Oh Young-Seon
Kim Yun-Jin
Kim Jung-Hyun
Kim Yoon-Sik
Seol In-Chan
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Abstract
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Background : Cerebrovascular disease is a major cause of death and disability in adults. Silent cerebral infarction (SCI) portends more severe cerebral infarction or may lead to insidious progressive brain damage resulting in vascular dementia. Known cardiovascular risk factors, such as arterial hypertension, diabetes mellitus, smoking, hyperlipidemia and ischemic heart disease may increase the risk of SCI. This study was designed to evaluate the risk factors of SCI in an apparently normal adult population.
Methods : We divided 340 neurologically normal adults (mean age=59.908.30, men:women = 146:194) who underwent brain computed tomography (CT) or magnetic resonance imaging (MRI) at the Stroke Medical Center in Daejeon University Oriental Medicine Hospital in two groups, Silent inf. and Controls,and analyzed risk factors of SCI by interview, physical examination and blood test. Risk factors of SCI were assessed by interview, physical examination and blood test. We performed Pearson’s chi-square test and two-sample t-test for univariate analysis and multiple logistic regressions for multivariate analysis to evaluate risk factors of SCI.
Results : Old age, diabetes mellitus, and high lactate dehydrogenase (LDH) levels were associated with SCI on univariate analysis. Diabetes mellitus was demonstrated to be an independent risk factor for SCI on multivariate analysis.
Conclusions : Advanced age, diabetes mellitus, and LDH levels are associated with SCI.
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KEYWORD
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silent cerebral infarction, risk factor, case-control study
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